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| updated 1.08.2010 | Home Journals Labs | |||
| My recent scientific articles | ||||
Working Address: Group of Prof. Dr. Hannah Monyer,
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We could win a coverpage by NEURON!!! The Extracellular Matrix Molecule Hyaluronic Acid Regulates Hippocampal Synaptic Plasticity by Modulating Postsynaptic L-Type Ca(2+) Channels Although the extracellular matrix plays an important role in regulating use-dependent synaptic plasticity, the underlying molecular mechanisms are poorly understood. Here we examined the synaptic function of hyaluronic acid (HA), a major component of the extracellular matrix. Enzymatic removal of HA with hyaluronidase reduced nifedipine-sensitive whole-cell Ca(2+) currents, decreased Ca(2+) transients mediated by L-type voltage-dependent Ca(2+) channels (L-VDCCs) in postsynaptic dendritic shafts and spines, and abolished an L-VDCC-dependent component of long-term potentiation (LTP) at the CA3-CA1 synapses in the hippocampus. Adding exogenous HA, either by bath perfusion or via local delivery near recorded synapses, completely rescued this LTP component. In a heterologous expression system, exogenous HA rapidly increased currents mediated by Ca(v)1.2, but not Ca(v)1.3, subunit-containing L-VDCCs, whereas intrahippocampal injection of hyaluronidase impaired contextual fear conditioning. Our observations unveil a previously unrecognized mechanism by which the perisynaptic extracellular matrix influences use-dependent synaptic plasticity through regulation of dendritic Ca(2+) channels. pdf Published: "NEURON" , July 15, 67(1):116-128, 2010 |
my CV & Publications pdf my PhD Thesis pdf |
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The neural cell adhesion molecule (NCAM) is the predominant carrier of 2.8 polysialic acid (PSA) in the mammalian brain. Abnormalities in PSA and NCAM expression are associated with schizophrenia in humans and cause deficits in hippocampal synaptic plasticity and contextual fear conditioning in mice. Here, we show that PSA inhibits opening of recombinant NMDA receptors composed of GluN1/2B (NR1/NR2B) or GluN1/2A/2B (NR1/NR2A/NR2B) but not of GluN1/2A (NR1/NR2A) subunits. Deficits in NCAM/PSA increase GluN2B-mediated transmission and Ca2 transients in the CA1 region of the hippocampus. In line with elevation of GluN2B-mediated transmission, defects in long-term potentiation in the CA1region and contextual fear memory in NCAM/PSA-deficient mice are abrogated by application of a GluN2B selective antagonist. Furthermore, treatment with the glutamate scavenger glutamic-pyruvic transaminase, ablation of Ras-GRF1 (a mediator of GluN2B signaling to p38MAPK), or direct inhibition of hyperactive p38MAPK can restore impaired synaptic plasticity in brain slices lacking PSA/NCAM. Thus, PSA carried byNCAM regulates plasticity and learning by inhibition of the GluN2B-Ras-GRF1-p38MAPK signaling pathway. These findings implicate carbohydrates carried by adhesion molecules in modulating NMDA receptor signaling in the brain and demonstrate reversibility of cognitive deficits associated with ablation of a schizophrenia-related adhesion molecule. pdf Published: "Journal of Neuroscience" , March 17, 30(11), 4171-4183, 2010 |
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| My recent pop-sci papers | ||||
A short practical assay about how to strengthen your mental power and memory by doing very simple mental exercises called neurobics pdf Published: "HEALTH" magazine, Rus Ed., "Здоровье", №7, p52-53, 2010 |
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A review about the most misterious mental disorder - scizophrenia, which affects nearly 1% of population worldwide. I outlined main molecular and genetics mechanisms involved in development of this desease. pdf Published: "Scientific American" magazine, Rus Ed., "В Мире Науки", №5, p47-55, 2010 |
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A big practical review about modern approaches and techniques for enhancing cognitive functions, memory and learning. Vitamins, brainy food, "smart drugs", natural herbal supplements, phisical exercises, mnemonic training etc. pdf Published: "HEALTH" magazine, Rus Ed., "Здоровье", №4, p48-52, 2010 |
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A big deep-in-details review about how our everyday life-style can alter gene expression which can be inherited in generations via epigenetic mechanisms. pdf Published: "HEALTH" magazine, Rus Ed., "Здоровье", №1, p62-64, 2010 |
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A review about so-called "smart-drugs" and other more natural ways to enhance our cognition, memory and learning. pdf Published: "Scientific American" magazine, Rus Ed., "В Мире Науки", №12, p36-43, 2009 |
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A review about post-traumatic stress disorder (PTSD) and interview with Gregory Quirk and Joseph LeDoux. Published: "GEO" magazine, Rus Ed., №9, p162-166, 2009 |
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A big review about influence of negative life-style factors, like alcohol consumption and tobacco smoking on human epigenome which leads to formation of different types of cancers and chronc disorders. pdf Published: "Scientific American" magazine, Rus Ed., "В Мире Науки", №9, p48-57, 2009 |
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An interview with Linda Avey, a CEO of one of the leading US personal genomics company "23andMe". pdf Published: "Scientific American" magazine, Rus Ed., "В Мире Науки", №2, p68-72, 2009 |
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A review about a role of epigenetic and life-style factors in altering of gene expression which causes various diseases and disbalances fine tuning of many molecular signaling cascades in the cells. pdf Published: "Scientific American" magazine, Rus Ed., "В Мире Науки", №11, p50-59, 2008 |
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A travel guide about amazingly beautiful and most visited German island - Helgoland in North Sea. pdf Published: "GEO Traveler" magazine, Rus Ed., Summer issue, p66-70, 2009 |
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A travel guide about German city - Hamburg. pdf Published: "National Geographic Traveler" magazine, Rus Ed., №4, p50-57, 2009 |
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An interview with one of the leading expert in the field of brain oscillations and their role in learning and memory. pdf A full interview (about 1.5 hr of conversation) with Dr. Buzsaki (in English) can be found here Published: "Scientific American" magazine, Rus Ed., "В Мире Науки", №10, p80-83, 2008 Useful links: Buzsaki's lab His book at Amazon.com Brain Science Podcast #31: Brain Rhythms with György Buzsáki 10 Questions to György Buzsaki Der Rhythmus der Gedanken, Sueddeutsche.de |
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A reportage about the FENS-2008 biggest in Europe neuroscience mmeting which took place in Geneva, Switzerland. pdf Published: "Scientific American" magazine, Rus Ed., "В Мире Науки", №9, p90-91, 2008 |
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A review about brain-computer interfaces (BCI) in gaming industry. pdf Published: "Scientific American" magazine, Rus Ed., "В Мире Науки", №6, p80-83, 2008 |
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A reportage about the biggest IT fair in Europe, CeBIT-2008 in Hannover, Germany. pdf Published: "Scientific American" magazine, Rus Ed., "В Мире Науки", №4, p92-93, 2008 |
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A reportage and photocaverage about a famouse Swiss castle Chillon. pdf Published: "National Geographic" magazine, Rus Ed., №9, p64-70, 2008 |
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| Oleg Senkov © 2010 All rights reserved | ||||
Neural Cell Adhesion Molecule-Associated Polysialic Acid Regulates Synaptic Plasticity and Learning by Restraining the Signaling through GluN2B-Containing NMDA Receptors
